Areas of Focus

• Mechanisms by which normal cells become cancerous with an emphasis on aberrant signal transduction pathways.
• Receptor tyrosine kinases to transcription factors.
• Oncogenesis at the basic science level, validating cancer-causing proteins and pathways, developing chemical probes to target such pathways, and ultimately performing biomarker-driven clinical trials.
• Focuses on understanding the mechanism by which mutant KRas causes cancer.

VCU Department of Pharmacology and Toxicology directory profile