Chemical Synthesis Lab

Advancing drug discovery through chemical synthesis, purification and structural characterization

Overview

The Chemical Synthesis Lab supports small molecule and peptide design, synthesis and characterization. The lab combines deep expertise and modern instrumentation to accelerate the development of biologically active compounds and research probes.

Equipment

Büchi rotary evaporator setup with condenser coil, round-bottom flasks, and temperature control unit on a lab bench — Buchi Rotvap

Stacked H.P.L.C. instrument with teal cylindrical components and solvent bottles beside it on a lab bench, part of an Akai system — HPLC: Varian Prostar

Waters Alliance H.P.L.C. system with multiple stacked modules, tubing, and an open sample tray on a laboratory counter — Waters Alliance

Biotage Selekt automated chromatography system with two solvent bottles on top and a touchscreen interface in a laboratory setting — Combiflash: Biotage Selekt

Thermo Scientific Nicolet i.S.10 Fourier-transform infrared spectrometer on a lab bench near a window, with a sample plate under the arm — IR: Thermo Scientific Nicolet iS10

Bruker UltraShield 400 Plus nuclear magnetic resonance spectrometer standing in a lab with cables and support structures — NMR: Bruker Ultrashield 400 Plus

Tall white analytical instrument on wheels with tubing connections, part of a mass spectrometry system in a laboratory — MS: Perkin Elmer AxION TOF Mass Spectrophotometer

Thermo Scientific Orbitrap Fusion Lumos mass spectrometer setup in a lab, with adjacent control units, tubing, and connected instruments — Thermo Scientific Orbitrap Fusion Lumos

Close-up of an Advion expressionL CMS mass spectrometer system on a laboratory bench, connected with tubing and a Plate Express interface unit beside it — TLC-MS: Advion Plate Express

Members

Lead: Shijun Zhang, Ph.D.
Yana Cen, Ph.D.
Yan Zhang, Ph.D.
Malgorzata Dukat, Ph.D.
Umesh Desai, Ph.D.
Matt Hartman, Ph.D.
Ashton Cropp, Ph.D.
Josh Sieber, Ph.D.